EXOSOMES
Pharmaceutical Grade MSC Exosomes
Exosome Diagnostic and Therapeutic Applications
Exosome Diagnostics
Simple, Accurate, Early Detection
Emerging scientific evidence indicates that the number, composition and contents of exosomes circulating throughout the body changes with aging and disease, presenting an opportunity for development of new diagnostic modalities.
Knowing that the exosomes produced by various cell types have different protein and miRNA profiles in different states of aging or disease, means that endogenous exosomes could be used for improved diagnosis of disease. Using advanced instrumentation for detection and characterization of exosomes, Kimera Labs® is developing ways to expand our understanding of how these changes in exosome contents correlate with different diseases.
New diagnostic modalities based on these exosome profile libraries of disease could have improved accuracy and earlier detection, and provide simpler methods of sampling than current diagnostic tests.
Exosome Therapeutics
Application of MSC Exosomes in Clinical Medicine
Ongoing research into MSC Exosomes presents a tremendous opportunity for development of biopharmaceuticals by providing a simple mechanism for delivery of therapeutic molecules.
Preclinical studies indicate that the naturally occurring proteins, messenger RNA and microRNA within MSC Exosomes improve the function of aging, injured or diseased cell, tissues and organs. Introduction of other therapeutic agents into these exosomes has also demonstrated impressive results in preclinical research. As an ideal vehicle for delivery, the lipid membrane of exosomes serves not only to protect exosome proteins and RNA from degradation, but also allows exosomes to reach cells in parts of the body that many drugs cannot. For example, exosomes are able to cross the blood-brain barrier and can penetrate solid tissue masses like the thyroid or tumors. Optimizing these properties and the contents of MSC exosomes developed for specific clinical indications may become the future of medicine.
MSC Exosome Properties
The intrinsic, biological properties of neonatal MSC exosomes demonstrated in laboratory studies indicate their potential as investigational biologic agents for the treatment of injury and disease. Kimera Labs® is investigating potential clinical applications of MSC exosomes as demonstrated in preclinical studies.
Clinical Applications
Developing future therapeutics
Understanding the principal cellular and biochemical mechanisms of disease and injury and how MSC exosomes could influence cellular behavior opens the door for research and development of the next generation of diagnostic modalities and therapeutic biologics.
Further study will indicate if neonatal MSC exosomes may form the foundation of novel treatments and cures for many autoimmune, inflammatory, degenerative, traumatic and malignant conditions by optimizing the activity of cells and tissues involved in pathogenesis of disease and injury.
Investigation of the biological effects of MSC exosomes with laboratory studies and clinical trials should be performed to demonstrate the safety and efficacy of exosome-based therapy for cardiovascular, neurologic, musculoskeletal and dermatologic conditions and more.