the Future STARTS HERE
Pioneering MSC-Derived Exosome Science
Advancing the Future of Exosome Science
Exosomes in Diagnostic Research
Emerging scientific evidence indicates that the number, composition and contents of exosomes circulating throughout the body change with aging and disease, presenting an opportunity for the development of new diagnostic modalities.
Exosomes produced by different cell types carry different protein and miRNA profiles across states of aging or disease. Using advanced instrumentation for detection and characterization, Kimera Labs® is expanding our understanding of how these changes correlate with disease.
New diagnostic modalities based on these exosome profile libraries could offer improved accuracy, earlier detection, and simpler sampling than current tests.
Exosome Innovation & Discovery
of Therapeutic Research
MSC-derived exosomes are being actively investigated as a promising platform for the delivery of therapeutic molecules. Their naturally occurring lipid membrane protects a diverse cargo of proteins, mRNA, miRNA, and other bioactive molecules.
Preclinical research has demonstrated their potential as efficient delivery vehicles, capable of transporting both native molecular cargo and engineered therapeutic agents.
Their small size and biological properties enable them to circulate throughout the body and reach tissues traditionally difficult to access, including crossing the blood-brain barrier.
The Biology of MSC-Derived Exosomes
One of the Most Promising Areas in Modern Biotechnology
Laboratory and preclinical research has highlighted the potential of MSC-derived exosomes as investigational biologic platforms, while ongoing discovery continues to expand our understanding of their role in cellular communication.
Kimera Labs is committed to advancing MSC-derived exosome science through rigorous research and innovation, exploring their potential across a broad range of future applications.
Anti-Inflammatory
By down-regulating inflammatory proteins like TNF-α, IL-1β and MMPs, and upregulating anti-inflammatory proteins like IL-4, IL-10 and TIMPs, MSC exosomes could reduce inflammation, which is a central mechanism of many autoimmune, inflammatory and degenerative conditions.
Anti-Oxidant
Exosomal proteins such as peroxiredoxins could reduce the oxidation state of cells under oxidative stress, which is present in many disease states and plays a role in tissue degeneration associated with aging. Reducing the oxidative stress on cells could improve their function and survival.
Anti-Apoptotic
By supplying diseased or degenerative cells with proteins and RNA that support essential cellular functions, MSC exosomes could exogenously maintain cell viability and prevent apoptosis. The anti-apoptotic message contained within these exosomes may help to slow, stop or reverse tissue degeneration.
Anti-Fibrotic
In preclinical studies, MSC exosomes optimize tissue remodeling in damaged skin and other tissues with improved type I/III collagen ratio and normal organization of collagen fibers. Reducing fibrosis during wound healing or after tissue injury could improve scar formation and tissues.
Immunomodulatory
By polarizing immune cells, such as macrophages and T-cells, to less inflammatory and more regulatory phenotypes, MSC exosomes could modulate the activity of immune cells to improve autoimmune disease and mitigate conditions characterized by excessive immune response.
Pro-Angiogenic
By stimulating endothelial cell function, MSC exosomes could improve angiogenesis. Improving the blood supply to injured or diseased tissues could help to increase the survival of damaged cells and prevent tissue degeneration and impaired function.
Pro-Synthetic
Activation of specific cells, such as fibroblasts, by MSC exosomes could enhance extracellular matrix production and help to restore damaged tissues. Specific exosome microRNA molecules could also help to regenerate normal collagen in the skin or stimulate production of normal articular cartilage.
Epigenetics
Proteins like histone deacetylases contained within MSC exosomes may induce transcription of inactive DNA and influence the functions of target cells without altering the genome. By altering the methylation patterns of DNA, dormant gene expression could be re-activated.
Areas of Scientific Investigation
Shaping the Future of Tomorrow
EXOSOME PROFILING
Advanced instrumentation used to profile exosome size, count, surface markers, and molecular cargo with consistency at every batch.
Diagnostics
Building exosome profile libraries that correlate cargo changes with aging and disease for earlier, simpler detection.
Delivery Platforms
Investigating the native lipid membrane as a protective vehicle for proteins, mRNA, miRNA, and engineered cargo.
Clinical Investigation
FDA Phase I/IIa IND clearance marks an important milestone in the clinical investigation of Kimera MSC-derived exosomes.